Among pregnant women with obesity, the use of metformin in addition to diet and lifestyle did not affect birth outcomes when compared with similar women who received placebo along with diet and lifestyle, according to findings from a randomized controlled trial in Australia.
“While metformin in addition to dietary advice reduced weekly pregnancy weight gain, it did not impact clinical pregnancy and birth outcomes,” Jodie Dodd, MD, PhD, professor in obstetrics and gynecology at the University of Adelaide and maternal fetal medicine specialist at Women’s and Children’s Hospital in North Adelaide, Australia, told Endocrine Today. “Metformin from early pregnancy for women who are overweight or obese is not recommended.”
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