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The World Welcomed its First ‘Designer’ Baby Recently 



We’ve blogged about research into 3-parent IVF designer babies before here in 2014 and here in 2012 but it looks like they’re here!

Well one anyway.

A couple gave birth in April to a baby who has DNA from his mom and dad; and also from a donor whose  DNA was used to replace a portion of mom’s DNA with a genetic predisposition to a deadly disease.

According to NYMag, a Jordanian couple welcomed a son on April 6, 2016 after going to Mexicio to have genetic splicing done to make sure the baby wouldn’t inherit a fatal condition.

He is said to be the world’s first so-called three-parent baby using a new IVF technique.

Mom carries a fatal disorder called Leigh syndrome. She had four miscarriages and lost two children, one at age 6 and another at 8 months to the disorder.

The genes for Leigh syndrome (and several other debilitating and fatal diseases) are found in mitochondrial DNA, which is passed only from mothers to their children. The three-parent-baby IVF technique replaces a mother’s mitochondrial DNA with that from a donor.

It is important to note that the technique has no effect on appearance or personality traits.

The U.K. approved the procedure in 2015 for research for purposes of studying why some embryos result in miscarriage 

A couple of years ago, the US Food and Drug Administration held hearings to discuss proposals to do the same here but it ultimately was not approved.

There is much opposition to this technique which ethicists say may eventually lead to designer babies where parents mess with a future baby’s DNA in order to welcome a baby with socially preferable features: think blue eyes, blonde hair, chiseled cheekbones, high IQ.etc.

Religious groups were concerned that researchers would harvest eggs not to be fertilized but to be destroyed later.

Because of the opposition and limits on use of the technique in the Western world, the couple went to Mexico to get the splicing done because regulations there are lax.

It reminds me of Gattaca, that Ethan Hawke Sci Fi movie about designer super  humans that the government bred for its army of perfect agents.

Early Ultrasound During Pregnancy Worsens Child Autism Symptoms, Study Says

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ULTRASOUNDS during early pregnancy could see autistic children develop more severe symptoms, research suggests.

A new Washington University study suggests that women that get ultrasounds early in their pregnancy and later give birth to a child with autism will see more severe symptoms in their children.

Researchers examined the ultrasound records of mothers to more than 100 autistic children.  All of the children involved all had a genetic variant which made them more likely to develop the condition.

The study found that autistic children of mothers who had ultrasound scans in the first trimester were more severely affected by their condition.

The scientists are not claiming that an early ultrasound may cause the autism but perhaps did cause the worsening of symptoms

“Don’t have ultrasound in the first trimester if there is no medical need – you may be putting your unborn fetus at unnecessary risk,” Professor Sara Webb, who led the research, told the UK Express.

But Professor Jim Dornan, from Queen’s University, Belfast, said: “Until there are more rigorous studies no conclusions can be drawn.”

Yes, we too get frustrated over the varying messages and conclusions that come out of the research industry, but for conditions like autism which is relatively still a mystery, the more information and any correlations, the better.

 

 

 

 

h/t UK Express

The Cost of Living in DC and 6 Other Most Expensive Cities in America

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If you want to live in the nation’s capital, it’ll cost you. While DC is great for relatively cheap family vacations thanks to an abundance of museums, living there is a different story.

DC tops the list of most expensive cities to raise kids thanks in large part to childcare costs. This hasn’t gone unnoticed by people, either: national news outlets have reported that the cost of an average DC daycare is more expensive than the average public college.

The other place where DC hits the wallet hard? Taxes. Between income taxes, Social Security, and Medicare, DC residents pay a hefty amount each month. Remember, though, that there are ways to reduce your taxes if you’re smart about it, like using tax-friendly investment products like IRAs, taking advantages of tax deductions, and hiring a professional to find deductions and write offs for you.

Parents want the best for their children, but how much does development, growth, and health cost in the “best city?”

If you live in Washington, DC you’re paying close to $1,500 in housing and $3,000 per month for child care alone!  We investigated how much basic necessities, schooling, child care, transportation and healthcare will cost the average family each year.

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PolicyGenius looked at the costs parents face every day, from setting aside money for savings to paying for school to sending your kid to summer camp, and pinned down the highest priced categories to bring you the most expensive cities to raise children – so you know where your next move will take you (and where you should just vacation) – along with some tips on making them a little more affordable.

Read more about the other 6 cities at Policy Genius. Watch its report here.

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Study: Zika Virus Lives in Vagina Long After Infection

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Just when you didn’t think it could get any worse, it gets worse.

A recent Yale University study discovered that the Zika virus may live in the vagina for days after infection. Researchers studied the vaginal tissue of pregnant lab mice several days after infection, the virus spread and infected the fetal brain and development but it also replicated itself robustly in the female reproductive tract more than at other sites of infection. The consequence of that rapid replication could be dire for reproduction.

The study was published online August 25, 2016 in Cell.

Before this report, it was not known whether the Zika virus replicated in the vagina after women were exposed through sexual intercourse. Also unknown was the potential consequences on fetuses after sexual transmission to pregnant women were also unknown.  Recent reports have confirmed sexual transmission of the Zika virus from infected men to uninfected women.

The researchers found that the Zika virus replicated in the vagina and persisted post-infection.

“We saw significant virus replication in the genital tissue, up to 4-5 days. With other routes of infection, theZika virus does not replicate unless you block type I interferons. What surprised us most was that the virus replicated in the vagina of wild-type mice with intact interferon response,” said Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute. “The finding may be important for women, not only pregnant women,” said Iwasaki. “The vagina is a site where the virus can replicate and possibly transmit to partners. In pregnant women, vaginal transmission of Zika virus may have a significant impact on the developing fetus.”

The study is also significant given the fact that, according to reports, Zika virus can also persist in semen up to 180 days post-infection, notes the Yale researcher. In addition, a recent report indicates that there can be a female-to-male transmission of Zika virus after vaginal intercourse. Combined, these studies paint a broader picture about the virus generally for those trying to eradicate and prevent it from spreading.

Other Yale authors include Laura Yockey, Luis Varela, Tasfia Rakib, William Khoury-Hanold, Susan L. Fink, Bernardo Stutz, Klara Szigeti-Buck, Anthony Van den Pol, Brett D. Lindenbach, and Tamas L. Horvath. The work was supported by the Howard Hughes Medical Institute, and the National Institutes of Health.

 

#TeacherBae: Social Media dubs Elementary School Educator ‘Too Sexy’

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A young Atlanta school educator has become the latest viral internet sensation once images of her curve-hugging dresses started circulating widely on the Internet. Social media users are referring to Patrice Brown, an award-winning school professional, as TeacherBae.

It doesn’t help that Brown’s Instagram is also filled with pictures of herself scantily dressed or in clothes some will consider seductive, and well…that’s just too hot for some on the Internet to handle. Well, not all. She quickly amassed a following of 160,000 shortly after she went viral.

Social media was abuzz with many  people proclaiming that Brown dresses too provocatively for a school, and since then, many others have spoken out in her defense.

The pretty educator reacted to all the fuss.

She told the Daily Dot,”I just wish they would respect me and focus on the positive and what truly matters—which is educating the children of the future generations and providing and caring for them.”

The school system she works for also felt compelled to issue a statement that included a declaration about the school policy.

According to the administrators, Brown isn’t a teacher, but a paraprofessional with the district and has been “given guidance regarding the APS Employee Dress Code.”

A skim of the district’s policy shows language regarding “immodest dress, tight or otherwise revealing” as being considered unacceptable, as well as jeans not worn for special projects and activities.

I guess it doesn’t matter that there are also images of her out there with her school children or that she was once named teacher of the month for her effort.

In a nutshell, Brown, like other women with large breasts, hips or buttocks, are sexualized just because of the size of their physical features. If a woman with smaller body parts wore the same outfit, she wouldn’t be told that she was too sexy.

A couple of years ago, another teacher, Becky Brinkerhoff who lived in a conservative Christian community wrote about her similar experience in the Thought Catalog in 2014.

“My curvy figure—the one that I could not help myself from having—automatically labelled me as sinful,” Brinkerhoff wrote . “I was being guilted for something that I couldn’t change. I was being held to an impossible standard of modesty—one that my body simply could not comply with.”

And curvy women have even lost their jobs simply for having a figure they were born with.

Back in 2010, a Citibank employee says she was fired because the men in her office thought she dressed inappropriately.

When she pointed out she was wearing the same clothing as other women in the office, “They said their body shapes were different from mine, and I drew too much attention,” Debrahlee Lorenzana  told the Village Voice. Citibank denied her claims, and did not enter a settlement with her.

Daily Dot pointed out how the issue of curvy bodies disproportionately affects women of color who are usually more curvy than White women.

“Women of color are so often sexualized through misplaced exotification,” writer Fariha Róisín noted in a January 2016 opinion piece in Fusion. “Before we’re old enough to gauge how the holes toiling inside of our bodies serve a purpose… We are simultaneously told we are ‘undesirable’ by the glaring lack of representation, and that we are, simultaneously, too sexual.”

I wrote about the “curvy girl problems” a few years ago too when our Bellytch Bumpwatch alum Erica Campbell was told the white curve-hugging yet fully covered turtleneck dress she wore for the cover of her first solo album was too sexy. 

I pointed out how the late Whitney Houston had wore a similar dress and because Houston had a very thin frame, she wouldn’t have faced the same negative feedback even while wearing the same type of dress.

 

Why Lady Gaga Fans Trolled Radio Stations as ‘Soccer Moms’

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Why did Lady Gaga‘s fanatical followers pose as soccer moms to get radio stations to play the long-awaited single from the mega star? Because they can.

The fan site GagaDaily started a campaign to support her by telling Gaga’s stans called monsters that “radio hosts hate homosexuals and stan twitters, it’s a fact”. Therefore, they aimed to create buzz for her new song, “Perfect Illusion“, before it was released. The “Bad Romance” singer’s stans encouraged all the fan site members to create fake accounts to appear like soccer moms.

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One post on a private bulletin board suggested to fans: “Make an account with a soccer mom selfie avatar, make your username something like ‘ilovemykids123’ and write a bio about how you have three kids and a husband.”

And so they did!



One member of a private board wrote, like “you will be helping radio DJ’s all over the world think that the GP [general population]is actually living for the song, therefore playing it more often,” the Guardian reported.

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Eventually, the radio stations started to pick up on it.

“You don’t need to send the fake soccer mom tweets, @ladygaga fans, you already KNOW we got you! #PerfectIllusion,” Pittsburgh station 96.1 KISS wrote. After all, most of the accounts were created this month. doh!

And for those stations who didn’t know, they could have learned about the contrived excitement when the story got picked up by sites like BuzzFeed and Paper Magazine.

“Numerous ‘soccer mom’ accounts have been set up, all barely a few hours old, with different stories about their daughters/sons/husbands and how much they absolutely MUST hear the new Gaga, or really any Gaga at all,” Buzzfeed reporter Brad Esposito wrote.

It’s been a busy summer for Gaga who recently released a cookbook with her father; confirmed a role in A Star is Born and she also just started filming the latest season of American Horror Story.

Parents Googled Their Perfect’ Sperm Donor, Discovered He’s A Mentally Ill College Drop out w/Criminal Past

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Some of the 30+ women who received donor sperm from the same man who claimed to be a PhD neuroscience engineer discovered via Google that he was unemployed college drop out with a criminal history and mental illness past.

They are among several who have sued Georgia company Xytext Corp for promoting James Christian (Chris) Aggeles as a highly educated, healthy and popular donor.

The lawsuits claim that the company never questioned the information that Aggeles entered into his questionnaire and that the Xytext misled donor recipient about his medical and social history.  Court documents indicate that Aggeles has suffered from schizophrenia, bipolar and narcissistic personality disorders.

The 39-year old turned himself into the police last month.  He is father to 19 boys and 17 girls from 26 families, a 2014 report indicates.

“I was contacted about a male in the police parking lot that said he had committed a fraud,” Det. Brigitte Menzel wrote in the report. “He informed me that he had falsified paperwork for a sperm bank, Xytex.”

Menzel’s report said Aggeles told her he “was not truthful” about his college degree status, and about some other information which was redacted in the report obtained by The Canadian Press. “Aggeles said that I could Google his name and there would be ample information available,” Menzel wrote. ”

A lawyer for Xytex said the company currently has no comment on the information in the police report. However, in the past, Xytex has said Aggeles was interviewed about his health, indicated he had no physical or mental impairments, and underwent a standard medical exam.

Nancy Hersh, a U.S. lawyer representing one of three Canadian women who have sued the company said the mothers first became suspicious of Aggeles’s history in 2014 after Xytex accidentally cc’d him in an email group chat set up by the company for mothers of the same donor.

“[The mothers] went to work, found out who he was, and found out everything they needed to know about him,” she said.

The company said it made it clear to the families that Aggeles’s information could not be verified for accuracy. Hersh disagrees.

“It was very easy for my clients to Google Mr. Aggeles when they found his name,” she said. “After we advised them of the information … they continued to deny that it was true,” Hersh claims. “So they either didn’t do their own due diligence … or they were lying.”

Hersh told the Canadian Press that she wants litigation to lead to action and regulation in the industry. “These are for­profit companies that make their money selling sperm and they have absolutely no incentive to do any background checks or any verification of anything as long as there’s no regulation and there’s no litigation,” she said.

REPORT: Parents Are Going Broke Putting Their Kids in Elite Sports Leaugues



The Olympics spark hope in many a child of going for the gold. But in financially supporting those dreams, some parents are going for broke.

For his 15-year old son’s travel hockey team, Tim Richmeier was spending about $5,000 a season: using his tax refunds, halting contributions to his 401(k), and putting travel expenses on a credit card — including $6,000 he’s still paying off. Richmeier said it was a great experience for his child. But after four years, it was a financial relief when his son didn’t make the team.

“I was kind of dreading the upcoming season, knowing I’d go deeper in the hole,” said Richmeier, a single father in Phoenix.

Competitive youth sports in the U.S. are rising in popularity. The exclusive club and travel teams come with added coaching and intense competition, as well as much higher costs than a school or community team.

Continue reading 

Are You Ready For Standing Desks in Schools?



Parents, standing desks soon may become the norm in classrooms. They are already used in a handful of schools nationwide as opposed to traditional chairs and desks. 

A recent study of Texas classrooms found that standing desks had a positive impact on the body mass index (BMI) of kids who use them. For two years, three unnamed Texas schools tested how standing desks might effect students’ BMI over time.

Researchers at Texas A&M tracked  around 400 kids and gave about half standing desks, while the rest had to work the old-fashioned way. The raised workspaces came with stools and bars underneath for the kids to rest their feet. 

All children wore research-grade activity trackers. After two years, the standers had overall lower BMI than the sitters. Researchers measured more than a 5 percent change in BMI between the two groups over time. 

One of the researchers, Dr. Mark Benden, director of the ergonomics center at Texas A&M, says these results shocked him. “This is crazy,” he said on first seeing the numbers. “Go back and rerun the numbers. Don’t breathe a word of this.”

Classrooms that use standing desks had kids with healthier outcomes.

After the study concluded, the Texas schools kept the standing desks and asked for more. 

Giving kids standing desks helps them burn more calories, and anecdotally, improves behavioral classroom engagement, the research concluded.

When  given a choice, parents don’t like sitting all day at work.

Recognizing the health consequences to static standing all day, Benden recommends a combination of the two.   

Read more about the study in Bloomberg

STUDY: You can Get an MRI in Early Pregnancy

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In an analysis that included more than 1.4 million births, exposure to magnetic resonance imaging (MRI) during the first trimester of pregnancy compared with nonexposure was not associated with increased risk of harm to the fetus or in early childhood, although gadolinium MRI at any time during pregnancy was associated with an increased risk of a broad set of rheumatological, inflammatory, or skin conditions and, possibly, for stillbirth or neonatal death, according to a study appearing in the September 6 issue of JAMA.

Concern has been expressed about the safety of MRI exposure in the first trimester of pregnancy due to the heating of sensitive tissues by radiofrequency fields and exposure to the loud acoustic environment. When indicated, MRI’s diagnostic accuracy is improved with gadolinium, an intravenous contrast medium. Fetal safety of MRI during the first trimester of pregnancy or with gadolinium enhancement at any time of pregnancy is unknown.

With the use of universal health care databases in the province of Ontario, Joel G. Ray, M.D., M.Sc., F.R.C.P.C., of St. Michael’s Hospital and the Institute for Clinical Evaluative Sciences, Toronto, and colleagues identified all births of more than 20 weeks from 2003-2015 to evaluate the long-term safety after exposure to MRI in the first trimester of pregnancy or to gadolinium at any time during pregnancy.

The study included 1,424,105 deliveries. In pregnancies that lasted a minimum of 21 gestational weeks, 1 in 250 had an MRI in pregnancy, including 1 in 1,200 in the first trimester and 1 in 3,000 with gadolinium contrast. Maternal MRI in the first trimester was not associated with a higher risk of stillbirth or neonatal death, congenital anomalies, neoplasm, or hearing loss.

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